Animals have always been a massive part of medical research. They are most commonly utilized in clinical trials, where we test the effectiveness and safety of new medications before moving on to human trials.^[1]

While animal testing is very crucial to the success of human medications, there are amazing lines of research involving animals in a less traditional sense. Some involve training animals to sniff out diseases, utilizing their body fluids for human treatment, or even using components of otherwise deadly venoms. Whether you are for or against animal testing, the things on this list will be sure to blow your mind!

10 Dogs Smell Cancer

There are many stories out there telling the tale of how a pet owner noticed their dog acting strange around them. Open further examination, they notice a lump or start feeling sick. After going to the doctors, they are diagnosed with cancer and have their dogs to thank for saving their life! But how does the science around this actually work?

It can really be chalked up to one thing: dogs’ amazing sense of smell. In our noses, we have olfactory receptors, which allow us to distinguish odors. The average human has approximately six million of these in their nose, while dogs have a whopping 300 million. This makes their sense of smell a lot more than just superhuman; it allows them to detect the slightest differences in the scents around them. What scent does a pet dog pick up on most often? Their owner, of course. Knowing this, it makes sense to think that dogs can even smell biological changes within us.

How effective is this method in terms of catching cancer early? A study using urine from prostate cancer patients found that dogs had a 91-percent success rate in identifying the cancer.^[2] Maybe sometime in the near future, we’ll see dogs used as a cancer screening method.

9 Animals Improve Symptoms Of Mental Illnesses

You’ve probably heard that animals have positive impacts on depression, but this isn’t the only mental illnesses that animals can improve. To list a few, animals aid in autism, ADHD, and anxiety.^[3]

Animals accomplish this by presenting social opportunities that would not arise otherwise. A good example of this is a depressed pet owner walking their dog. Also, exercise of any kind has been proven time and time again to alleviate symptoms of depression, as does being outside in nature. Pets can help improve sensory perception in autistic individuals and allow people suffering from ADHD to learn what routine is like and handle the responsibility of taking care of a living creature.

What pet owner doesn’t feel better after petting and cuddling their cat, dog, horse, rabbit, or any other pet out there? Knowing that an animal loves you unconditionally is a pretty special feeling and can lessen the mental burden of illnesses like depression and anxiety.

8 Zebrafish And Metabolic Disorders

In the United States, the vast majority of adults are either obese or overweight. In fact, 160 million (including both adults and children) are estimated to be overweight or obese. In an obese person’s body, there is an underproduction of or lack of sensitivity to leptin (a hormone that inhibits hunger and regulates fat stores) and a decrease in the body’s sensitivity to insulin (which regulates fat, carbohydrate, and protein metabolism). This is why obesity is considered a metabolic disorder, as hormones that regulate our metabolic system are being compromised.

Proteins found in zebrafish have been used in clinical trials involving mice that are being fed high-fat diets. Using these proteins as drug injections protected mice from the causes of obesity, explained above as the lack of sensitivity to necessary metabolic hormones.^[4] If this is could be applied to humans, this means that a simple injection could mitigate most of the harm caused by our Westernized diets. The results are remarkable and have opened up a huge area of research for the treatment of metabolic diseases.

7 Brazilian Viper Venom And High Blood Pressure

The venom of Bothrops jararaca, a Brazilian pit viper, can cause you hemorrhage (due to your blood being unable to clot) if you are bitten by it.^[5] This sounds terrifying, and the snake looks pretty terrifying, too. It comes as a huge surprise, then, that the venom of this deadly snake led to the discovery of the method used to treat another of America’s biggest health problems: high blood pressure.

If injecting this venom into you is deadly, how could this possibly be of help to us? The entire process is actually pretty revolutionary. Back in the past, medical researchers looked everywhere for the key to decreasing blood pressure. The Brazilian viper’s venom gave us that key. ACE inhibitors, the current treatment for high blood pressure, were originally developed from a peptide in the venom. These inhibitors block receptors in our body that tell our blood vessels to constrict, causing high blood pressure.

6 Childhood Blindness And Mice

While childhood blindness isn’t as common compared to other illnesses on this list, it is still very unfortunate. Children are born without one of their five main senses, making their life difficult from a young age. Giving sight back to someone who was born blind seems like an impossible miracle, but a linked gene found in mice could make this possible.

A 2006 study dealt with childhood blindness caused by defective genes, meaning that the proper cells that allow us to see aren’t created. This model was recreated in mice by knocking out the same gene that is missing or damaged in blind humans. When using gene transfer to reintroduce a healthy version of that same gene, the mice were able to begin producing the necessary cells for sight.^[6]

5 Giant Pandas’ Antibacterial Blood

Giant pandas look cute and cuddly, and their benefits to humans are proving to be so much more than just their adorable exterior.

Pandas happen to ingest and encounter a lot of types of bacteria in their natural habitats. Due to their constant exposure, their bodies have evolved to produce multiple strains of natural antibiotics. We can derive specific compounds from the panda’s genomes and use them to produce a diverse range of antibiotics that can fight bacteria and fungi.

This is significant because the antibiotics pandas produce have been found to kill certain strains of bacteria six times faster than the antibiotics we currently use.^[7]

4 Cats’ Purring Heals

This one is pretty mind-blowing. There is legitimate medical research that backs up the healing properties of a cat’s purr. If there wasn’t enough reason to own a cat, this should push aspiring cat owners over the edge.

There are a couple frequencies that promote bone growth and healing; they are 25 and 50 hertz.^[8] These low frequencies also happen to be in the range of cat purring, anywhere between 25 to 150 hertz. Scientists hypothesize that the reason cats purr is to promote self-healing, using their own frequencies to help with any internal bone injuries. This would also explain why cats purr when they are under stress or in pain.

The pressing question is whether it really benefits human bones as well. There is no scientific research directly supporting this theory, but many studies have shown that pet owners live longer. If cat purring was a contributing factor to this, that would be pretty amazing.

3 Dolphins Could Make Us Super-Healers

Imagine getting a shark bite and not suffering that much for it. Shark bites may not be lethal the majority of the time, but we still have to go to great lengths to properly heal the wound. Stitches, antibiotics, and other measures need to be taken to ensure that the wound closes and doesn’t get infected.

Large injuries observed on dolphins (presumably caused by sharks) require no special attention at all to heal. Their injuries healed in only weeks, despite the wounds being significant. The dolphins showed no signs of intense pain or discomfort from their injuries, and no permanent damage was dealt to them.^[9]

This strength of healing is unheard-of in any human suffering from an injury of this magnitude. So how do dolphins do it, and how could this benefit us?

Scientists suspect dolphins don’t bleed or get infections due to their “diving reflex,” which diminishes blood flow. Natural antibiotics found in their blubber ensure that no life-threatening infections occur. Similar to the giant panda on this list, we can utilize these antibiotics as well as learn a lot from their amazing healing properties.

2 Hibernating Mammals And Synapse Repair

The human brain uses synapses to pass signals from neuron to neuron. This process is essential for everything we do, from exercising to sleeping. We struggle to repair damaged synapses, this is why neurodegenerative diseases are so dangerous. However, a recent breakthrough allowed us to observe synapses that undergo significant cooling but still function after the cooling is over. Hibernating mammals manage this, though the study in question used artificially cooled mice.

The study was able to link a specific RNA-binding protein (RBM3), which was responsible for restoring the synapses after the severe body cooling.^[10] If this protein is removed, there is a significant reduction in synapse repair. This data supports the necessary presence of RBM3 for synapse and neuron health as well as the possibility of using gene therapy to increase production of RBM3 in patients with neurodegenerative diseases.

1 Scorpions And Brain Tumors

Scorpion venom is yet another type of venom that you wouldn’t expect to both help and harm humans. The scorpion in question is Leiurus quinquestriatus, more commonly known as the deathstalker. That name speaks to the nature of this scorpion—it’s pretty deadly. The mix of neurotoxins in its venom is extremely dangerous; get stung by it, and you’ll need to be rushed to the nearest hospital.

Unlike the snake venom mentioned before, the compound utilized comes straight from the scorpion venom, and its name is chlorotoxin. This chemical can target brain tumors originating in the top of the spine and brain.^[11] The discovery of chlorotoxin has justified research into other scorpion toxins, and more testing is needed to see just how effective other species’ venom is.

Operating on tumors within the brain and spine is very risky. One wrong move, and the surgeon can cause irreversible damage. This makes chlorotoxin even more valuable. If we can fight tumors without operating, many risks are alleviated.

It is weird to think that diseases can be used to cure other diseases. However, it is true. For centuries, scientists have figured out ways of using deadly, pathoegenic bacteria, viruses, and protozoa to cure deadly diseases caused by other pathogens.

It may seem counterintuitive to cure one illness with another, but it has worked time and time again. And it’s not always that scary. Other microorganisms, specifically viruses and bacteria that are not necessarily dangerous to humans, have also been utilized to treat lethal diseases.

10 Malaria

Syphilis was incurable throughout most of history and often led to death within four years. The worst form is neurosyphilis, which is infection of the nervous system by syphilis and often the final stage of the disease. Neurosyphilis is accompanied by blindness, madness, paralysis, and, subsequently, death. Most syphilis patients were confined to asylums until they died.

Austrian psychiatrist Dr. Julius Wagner-Jauregg started developing a treatment for syphilis in the 1880s. He turned to pyrotherapy—the artificial induction of a fever, in this case by the introduction of a more manageable pathogen. The high fever caused by the introduced infection kills off the incurable disease, and the curable disease is treated thereafter.

Dr. Wagner-Jauregg unsuccessfully tried using tuberculosis antigen as well as the typhus and typhoid vaccines to cure syphilis. However, he got his break in June 1917, when a wounded soldier suffering from malaria was sent to the psychiatric ward of the hospital where he worked. This was clearly an error because the soldier had no mental issues. But the doctor seized the opportunity to work on his pyrotherapy treatment for syphilis.

Dr. Wagner-Jauregg extracted blood from the soldier and injected it into nine people suffering from advanced syphilis. The malaria-causing Plasmodium protozoa caused a serious fever that killed off the syphilis-causing Treponema pallidum bacteria. Dr. Wagner-Jauregg went on to cure the six survivors—who now had malaria—with quinine.

Dr. Wagner-Jauregg published his findings in 1918. He noted that syphilis is killed when the body maintains a temperature of 41 degrees Celsius (106 °F) for six hours. His treatment soon became the method of choice for syphilis. However, it had its downsides, even though it was considered successful.

Syphilis patients often suffered from complications when they were injected with a different blood type. They also inherited the blood diseases of their donors. The deadly malaria strain used at the time could also cause anemia and kidney failure. Doctors later switched to the less deadly Plasmodium vivax strain. This method of treatment was abandoned after the advent of antibiotics.^[1]     

9 HIV

It is especially surprising that one of the world’s worst diseases can be used to treat other deadly ailments. Scientists have discovered a way to use HIV to cure leukodystrophy and Wiskott-Aldrich syndrome, two deadly diseases that often affect children.

To be clear, we do not use HIV itself but viral vectors created in part from HIV. A viral vector is used to deliver genetic material into cells, as in gene therapy. In 2010, a team of Italian doctors led by Dr. Luigi Naldini injected 16 children with HIV-based viral vectors. Six had Wiskott-Aldrich syndrome, while the other ten suffered from leukodystrophy.

Three years later, they observed that six of the children were slowly recovering from the diseases. Three suffered from Wiskott-Aldrich syndrome, and the other three suffered from leukodystrophy.^[2] The other ten were also showing some signs of recovery. The procedure is inconclusive because it is still undergoing clinical trials.

8 Cancer

CRISPR (pronounced “crisper”) means “Clustered Regularly Interspaced Short Palindromic Repeats.” It is used in the CRISPR-Cas9 gene editing technology that allows scientists edit the DNA in cells.

While scientists concentrate on using CRISPR to modify unfavorable genes, researchers at the Rutgers Cancer Institute of New Jersey are trying to use it to cure cancer. CRISPR works for cancer treatment because cancerous cells roaming in the body tend to circulate back to the tumor they originated from.

Using CRISPR technology, researchers at the Rutgers Cancer Institute injected these cancerous cells with the cancer-killing S-TRAIL protein. The S-TRAIL-containing cancerous cells killed other cancerous cells in the tumors when they entered them. Then they essentially self-destructed thereafter. The technology has not been tested on humans, though, and experiments have been confined to mice.^[4]

7 Cowpox

The cowpox virus was used to create the first vaccine for smallpox, a lethal virus that infected millions of people until it was declared eradicated in 1977. The cowpox vaccine is the reason vaccines are called vaccines. The name was derived from vaccinus, the Latin word for “cow.”

While we credit England’s Dr. Edward Jenner for creating the first smallpox vaccine, we know ancient Chinese and Middle Easterners deliberately infected themselves with cowpox to make themselves immune to the virus for centuries.

Dr. Jenner created the smallpox vaccine after observing that milkmaids never contracted smallpox. He later realized this was because they had been infected by cowpox—a closely related virus—from the cows they milked. Dr. Jenner proved his theory right in 1796, when he deliberately infected eight-year-old James Phipps with cowpox.

Dr. Jenner infected Phipps with smallpox a month and a half after infecting him with cowpox. Phipps never developed smallpox, indicating that he was immune to the virus. Dr. Jenner later published his findings. The smallpox vaccine which later eradicated the disease was derived from the vaccinia virus, another closely related virus.^[4]

6 Poliovirus

Poliovirus causes polio, which used to be one of the deadliest diseases out there. Fortunately, it is on the brink of extinction today. Only 22 incidents of polio were reported in 2017, which is a far cry from the 350,000 cases reported in 1988.

Interestingly, scientists are developing a method of using the once-deadly disease to cure glioblastoma (GBM), a rare but deadly and highly aggressive form of brain cancer. Glioblastoma is treated with surgery, radiation, and chemotherapy. However, it often returns and kills the patient within about a year.

The poliovirus therapy was developed by researchers from Duke Cancer Institute, Durham, North Carolina. They genetically modified the poliovirus to create a new virus called PVSRIPO, which is injected right into the brain tumors caused by glioblastoma.

A clinical trial conducted on 61 glioblastoma patients indicated a 21-percent survival rate. That seems small until we realize that patients given the standard treatments have a survival rate of just four percent.

While PVSRIPO looks promising, it could cause some unfavorable side effects depending on the location of the tumor in the brain.^[5]

5 Bacteriophage Therapy

In 2015, 69-year-old Tom Patterson was diagnosed with pancreatitis (inflammation of the pancreas) while visiting Egypt with his wife. Conventional treatment did not work, and he was later flown to Frankfurt, Germany. Doctors drained the fluid around his pancreas to discover he was infected with drug-resistant Acinetobacter baumannii bacteria.

Patterson was later flown to Thornton Hospital, San Diego, California, where a drain was inserted around his pancreas to control the dripping. Unfortunately, the drain slipped, and the fluid leaked into his abdomen and bloodstream. Patterson soon started experiencing high fever, serious pains, and breathing difficulties. He also fell into a coma that lasted for about two months.

Doctors settled for bacteriophage therapy as a last-ditch effort to save his life. Unlike what the name suggests, bacteriophages are viruses and not bacteria. The name means “bacteria eater” and refers to a distinct class of viruses that attack bacteria. Every bacterium has a bacteriophage that has evolved to use it to replicate.

Bacteriophage therapy refers to the use of these bacteria-attacking viruses to cure bacterial infections. It was the go-to method of dealing with deadly bacteria until antibiotics came along. However, its results are not scientifically proven.

Nevertheless, the therapy worked, and Patterson was slowly recovering from the coma—until the A. baumannii bacteria mutated and developed resistance against the virus. Doctors solved this problem by passing a newer strain of the virus into Patterson’s body until he was finally cured.^[6]

4 Maraba Virus

Scientists have always known that the Maraba virus (aka MG1 virus) attacks and destroys cancer cells. However, scientists at the Ottawa Hospital and the University of Ottawa have discovered that the Maraba virus also attacks and destroys HIV-infected cells.

HIV works by infecting and rapidly multiplying in the immune system cells of its hosts. However, some HIV-infected cells turn dormant after some time, while others continue to reproduce.

Doctors often administer antiretroviral drugs to suppress HIV. However, the drugs only work on active HIV-infected cells and have no effect on the dormant cells. The dormant cells kick into action and begin to rapidly reproduce when the patient stops taking the antiretroviral drugs.

Lab tests have proven that the Maraba virus will destroy dormant HIV-infected cells, indicating a possible cure for HIV. However, the procedure is considered inconclusive since tests have only been conducted in the lab, and this method has not been tested on animals or humans.^[7]
 

3 Coley’s Toxin Treatment

Coley’s toxin treatment involves use of bacteria to treat cancer. The procedure is named after William Coley, a New York bone surgeon who developed it in the 1890s. Coley invented the treatment after observing that patients who get infected with bacterial diseases while recovering from cancer surgeries were often better off than uninfected patients.

Coley believed this happened because the bacterial infection strengthened the patient’s immune system. So he began injecting live bacteria into his cancer patients. He later switched to using dead bacteria, given that live bacteria could still cause deadly infections.

Scientists do not agree on how the process works. Some think the injected bacteria strengthen the immune system against cancer cells. Others think the bacteria actually encourage the production of either a protein called interleukin 12 (IL12) or tumor necrosis factor (TNF) proteins that fight cancerous cells. Another group think it’s high fever that kills the cancerous cells, just like the pyrotherapy procedure we mentioned earlier.

Nevertheless, Coley’s toxin treatment had mixed results. It worked with some patients but did not work with others. However, it was widely used until the early 1950s, when it was displaced by other cancer treatments like chemotherapy. An improved version utilizing genetically modified bacteria is still used today.^[8]

2 Predatory Bacteria

Predatory bacteria are those that attack and eat other microorganisms. Predatory bacteria work by attacking and breaching the walls of enemy bacteria cells. Once inside, it eats the bacterium’s innards before reproducing and leaving to attack other, similar bacteria cells.

Scientists are already working on using predatory bacteria to treat other bacterial infections, especially superbugs that have become immune to regular antibiotics.

In November 2016, the BBC reported that scientists at Imperial College London and the University of Nottingham had successfully used the Bdellovibrio bacteriovorus predatory bacteria to kill Shigella, a deadly genus of bacteria that causes food poisoning and kills over a million people a year.

Scientists observed Shigella populations reduce by 4,000 times after exposure to B. bacteriovorus in the lab. Another test in fish larvae saw the survival rate of the larvae infected with Shigella increase from 25 percent to 60 percent. Scientists plan on testing B. bacteriovorus on other deadly human bacteria, including Salmonella and E. coli.^[9]  

1 CAR-T Therapy

T-cells play a vital role in the body’s immune system. Recently, scientists have developed a method of using the T-cells to create chimeric antigen receptor T-cell therapy (CAR-T therapy), an anticancer treatment.

CAR-T therapy works by extracting the natural T-cells in the body and programming them with chimeric antigen receptors, which greatly improve their ability to detect, bind to, and destroy cancerous cells. The genetically modified T-cells are tailored to target the specific cancer affecting the patient, making them the perfect cancer cell assassins.

However, CAR-T therapy is only used as an option of last resort because it can cause a myriad of side effects, including brain inflammation. The process is also time-consuming, since the T-cells need to be tailored to the patient. The entire procedure could take four months.^[10]