The story of Henrietta Lacks is as astounding as it is miraculous. A poor, black tobacco farmer from southern Virginia, Henrietta was diagnosed with a type of cervical cancer that was extremely aggressive.

Scientists had been trying to cultivate human tissue in the lab for many years without success. But after Henrietta’s tumor was biopsied, the answer finally came. The events that followed created a ripple effect so great that the world of medicine was never the same.

10 Henrietta’s Tumor Produced The First Immortal Human Cells Grown In Culture

In January 1951, Henrietta made the journey to Johns Hopkins Gynecology Clinic after she began bleeding profusely. She received her cervical cancer diagnosis, had a small sample taken of her tumor, and was given radiation and surgical treatment. Unfortunately, Henrietta’s cancer spread so quickly that nothing could be done to save her. She died in October that year.

Henrietta’s tissue sample was sent to Dr. George Otto Gey, the head of tissue culture research at Johns Hopkins. For years, Gey had been trying to produce a line of cells that could live eternally in a laboratory environment.

At last, he succeeded by using his own cultivation technique. It involved bathing the cells in a fluid of chicken plasma, beef embryo extract, and human placental cord serum. Upon observation, Gey discovered that Henrietta’s cells were rapidly and continuously multiplying.

In less than two years, Henrietta’s tissue samples were packaged carefully and distributed all around the world. The cells were called “HeLa” cells after the first two letters of Henrietta’s first and last names.

It should be noted that the number of HeLa cells grown to date spans more than 105 kilometers (65 mi), capable of wrapping around the Earth’s equator more than three times.

Despite being cancerous, HeLa cells behaved like normal cells in the body. This allowed scientists to learn how they reacted in certain environments. Research possibilities that were once off-limits or unethical suddenly became a reality as scientists started to understand how cell division occurred or how a virus affected a cell.

One woman’s tragic end was the beginning of a remarkable future in science and medicine.

9 Her Cells Were Taken Without Her Knowledge Or Consent

In the 1950s, it wasn’t considered unethical to use someone in a scientific study without his permission or to provide unauthorized medical treatment. There were no laws to protect the rights of people like Henrietta who had their privacy violated by researchers.

Dr. Gey initially attributed the scientific miracle to an imagined woman named “Helen Lane” in attempt to conceal Henrietta’s true identity. It wasn’t until many years later that the truth came to light.

Although Henrietta did not receive the recognition that she rightly deserved at the time, Gey seemingly had the right intentions. He is said to have devoted his life to culture research, going so far as to use his family and himself for his studies.

His only hope for the cells was that they would have the scientific impact that they actually did at the time. Although Gey had financial struggles of his own, he never sold any of Henrietta’s tissue samples. However, many companies and industries would later profit from Gey’s HeLa cells.

8 The Case Of The Immortal Cells Was A Medical Mystery

For years, scientists were baffled as to why Henrietta’s cancer cells replicated so quickly and aggressively without dying. Some proposed that it may have been a combination of human papillomavirus (HPV) and Henrietta’s DNA that caused the cells to react as they did.

Furthermore, it was found that she had syphilis, which results in an aggressive growth of cancer cells due to a weakened immune system. But it wasn’t until 2013 that a highly probable answer surfaced.

According to a study by University of Washington researchers, the scrambled HPV genome (which contains cancer genes of its own) inserted itself near an oncogene (a gene that can cause cancer when altered) in Henrietta’s genome. This activated the oncogene and caused the rapid replication of HeLa cells in Henrietta’s body.

“This was in a sense a perfect storm of what can go wrong in a cell,” said Andrew Adey, one of the study’s authors. “The HPV virus inserted into her genome in what might be the worst possible way.”

7 The Lack Family Was Kept In The Dark About HeLa Cells

Although Henrietta’s cells helped to save millions of lives, neither she nor her family benefited from it. Initially, her family had no idea that her cells were used in the groundbreaking accomplishment. When Bobette Lacks, Henrietta’s daughter-in-law, coincidentally met a cancer researcher years later, Bobette learned that Henrietta’s cells had been growing since her death in 1951.

Sadly, the treatments that were developed using HeLa cells were out of reach for the Lacks. Like many others without insurance, the Lacks could not afford them. Henrietta’s husband had prostate cancer, their eldest daughter had developmental issues, and another daughter had a host of medical issues that they were unable to treat. The family that should have been compensated simply wasn’t.

In an unexpected twist of fate, the Lacks family finally received some reparation in 2013 for their matriarch’s contribution. A research team at the European Molecular Biology Laboratory had sequenced and published Henrietta’s genome without the consent of her family.

Upon hearing about the publication, Henrietta’s grandchildren felt as though this further research would violate their family’s private medical history. They took a stand and requested that the scientists retract their study.

The family eventually agreed to allow the publication of much of the information about Henrietta’s genome.

6 HeLa Cells Were Instrumental In Early Cancer Research

Thanks to studies done with HeLa cells, researchers have learned a lot about the operation of cancer cells. It was discovered that Henrietta’s cancerous cells activated an enzyme called telomerase that the cells used to repair damaged DNA. This meant that HeLa cells proliferated and thrived as opposed to regular cells that simply died after a short time.

Scientists also learned that telomerase encouraged elongation of the chromosomes. In normal human cell division, telomeres (the tips of the chromosomes) become shorter after each division. After a while, the cells are destroyed because the telomeres can no longer shorten.

In HeLa cells, however, this process is a little different. As telomerase is hyperactive in HeLa cells, the telomeres never become depleted. The resulting continuous division of cancer cells has made the cell line vitally important for cancer studies—even today.

These discoveries have led to further research that has brought about advancements in cancer treatments.

5 HeLa Cells Aided The Progression Of Genetic Research

In 1953, a Texas geneticist was working with HeLa cells when a chemical accidentally spilled on them. However, this potential disaster turned out to be a blessing in disguise. Upon observation, the scientist noticed that the chromosomes within the cells increased in size and essentially untangled themselves, making them more visible.

Two years later, Joe Hin Tjio and Albert Levan developed an improved technique that led to the discovery that normal human cells definitely have only 46 chromosomes. Before this breakthrough was made, it had been incredibly difficult to count the chromosomes due to the small size and compact structure of DNA.

Furthermore, it had been widely accepted that humans had 48 chromosomes—like chimpanzees and gorillas. Thanks to Tjio and Levan, this theory was dispelled. This finding was monumental because it allowed the diagnosis of genetic diseases when someone’s cells were found to have more or fewer than 46 chromosomes.

4 Research Using HeLa Cells Led To The Creation Of The Cervical Cancer Vaccination

In 2008, German virologist Harald zur Hausen was awarded the Nobel Prize for his milestone discovery that two strains of HPV were directly linked to cervical cancer. In the 1970s, it was believed that herpes simplex caused cervical cancer.

But zur Hausen, who worked with the HeLa cell line, found that the genes of certain strains of the virus, including HPV16 and HPV18, maneuvered themselves inside the cells of the cervix and caused abnormal cell replication.

Years before zur Hausen’s success, scientists had been working toward an HPV vaccine that would prevent the virus and reduce the risk of cervical cancer among women. During the 1990s, scientists affiliated with the National Cancer Institute identified certain proteins on the outside of the virus that were similar to the virus itself. This was a major development because the proteins were found to stimulate the growth of antibodies.

All of this research led to the formulation of Gardasil and Cervarix, two HPV vaccines that are on the market today.

3 HeLa Cells Had Contaminated Other Cell Cultures Worldwide

In 1966, geneticist Stanley Gartler was working with sample tissues when he noticed something odd. All of the cells contained an enzyme called glucose-6-phosphate dehydrogenase-A (G6PD-A).

Gartler was puzzled because he knew that the tissue samples were taken from Caucasians and even animals. G6PD-A is an enzyme that is only found in humans and almost exclusively in African Americans. This was troubling because it meant that Gartler’s samples, as well as many others, were contaminated.

Gartler theorized that the culprit was the HeLa cell line. After initial doubts from other scientists—who feared the potential loss of millions of dollars—Gartler’s suspicions were confirmed. Proper care had not been taken to prevent samples from becoming contaminated as they were transferred between laboratories. Millions of dollars of research went down the drain.

It was discovered that HeLa cells could travel through the air. At that time, laboratories were not properly equipped to stop it. Luckily, improvements to inhibit such errors have been made to cell culture techniques since then.

2 The Involvement Of HeLa Cells Helped To Create The Polio Vaccine

Jonas Salk was a researcher at the University of Pittsburgh whose years of tireless work led to the end of the polio epidemic that swept through the US in the 1950s. Before Salk’s polio vaccine could be completed, however, he needed massive quantities of tissue samples for his work.

Luckily, the National Foundation for Infantile Paralysis was willing to fund a facility at Tuskegee Institute that was specifically geared toward the production of HeLa cells. Once equipped with the cancer cells, Salk was able to carry out testing on a large scale.

On April 26, 1954, tests began on nearly two million American, Finnish, and Canadian children. When the results came back, it was great news—the vaccine was safe and effective. Since then, the vaccine has become a staple of child healthcare around the world.

1 Some Scientists Suggest That HeLa Cells May Be A New Species

According to evolutionary biologist Leigh Van Valen of the University of Chicago, HeLa cells have no connection to people. Van Valen and other scientists claim that the cells are microbial in nature, bear no resemblance to human cells, and should be considered as an entirely new species.

It is believed that HeLa cells have genetically evolved over time to adapt to their environment—the petri dish—as a result of natural selection. Reportedly, there are now new strains of HeLa cells that have arisen in recent years.

Another study suggests that the process by which cancer cells are generated is the basis for the creation of a new species. It also makes mention of tumors that should be thought of as “parasitic organisms.”

Researchers have now proposed a new scientific name for HeLa cells—Helacyton gartleri—after Stanley Gartler who recognized how successful HeLa cells actually were.

There is a distinct difference between non-embryonic and embryonic stem cells. As the name implies, embryonic stem cells are liberated exclusively from human embryos. A human embryo exists as soon as the first mitotic division of a fertilized human egg occurs.

Unlike the stem cells from umbilical cords or the ones found naturally in our bodies, embryonic stem cells can grow into any cell type. This doesn’t mean that umbilical and adult stem cells are useless; they are simply limited in the way they can be applied to certain research methods.

The benefits of stem cell research range from fighting cancer to improving genetic disorders. Despite their benefits, the question remains: How ethical is their use?

10 Corneal Damage

We need our eyes for almost everything we do. Unfortunately for many people, congenital and acquired diseases leave them with partial or full blindness. In America alone, over 35 million people suffer from these diseases, resulting in a steep cost of $139 billion per year.

Many eye diseases can benefit from stem cell treatment. One study showed a 76.6 percent success rate when stem cells were used to regrow healthy corneal tissue in patients who had loss of vision.

This was accomplished by obtaining healthy corneal cells from an organ donor. These cells were then cultured with embryonic stem cells and multiplied until there were enough to insert into the patient’s body.^[1]

9 Osteoarthritis

If you are close with your grandparents or any elderly people at all, we’re sure you’ve heard of this one. Osteoarthritis is the most common joint disorder in America.

In a study published in the early 2000s, stem cells from adult bone marrow were used to protect the cartilage around joints which chronically breaks down when someone suffers from osteoarthritis.

The results were amazing. An injection of stem cells directly into the joint completely stopped the degeneration of the cartilage. This could theoretically stop the disease in its tracks in humans, making sure that it does not progress beyond a manageable state.^[2]

8 Liver Disease

Usually, our livers do a good job of repairing themselves. It is the only organ in our bodies that can regenerate. Problems arise when the damage to our livers has progressed too far, resulting in scar tissue that cannot be replaced. This scarring can be caused by obesity, alcoholism, diabetes, and many other ailments.

The stem cells in adult bone marrow can be used to jump-start the liver’s reparative abilities, leading to recovery of highly damaged liver tissue and prevention of liver failure.^[3] This could save countless lives as the liver is an organ that we cannot live without.

7 Heart Attacks

This one hits close to home for many people. It’s hard to find a family that doesn’t know the pain of a loved one or even themselves suffering from a heart attack.

A heart attack occurs when there is a blockage in a coronary artery leading to the heart. The heart tissue begins to die as there is limited or no access to oxygen. Our hearts cannot regenerate, and this damage can be fatal.

Embryonic stem cells were used to treat mice who had suffered heart attacks. The stem cells mimicked cardiac cells perfectly, showing evidence of probably using the electrical impulses that make our hearts beat. If treated with stem cells, heart attack survivors might significantly reduce their risk of a second episode while also minimizing the damage their heart attack caused.^[4]

6 Spinal Disk Disorders

What is the number one thing that people complain about as they get older? “Ouch, my back hurts.” The sheer number of spinal issues is remarkable. In fact, 80 percent of Americans will have a back problem at some point in their lives.

Spinal disks are bone with a fluidlike inside that is sandwiched between our vertebrae. The purpose of these disks is to provide us with a range of motion and shock absorption. They naturally become thinner as we age due to the inability to regenerate this bone tissue. To combat this, adult stem cells were injected into the decaying disks of rabbits.

The results revealed a spectacular increase in the spinal disk cells, making the entire spine healthier.^[5] This is a perfect example of how stem cells can be used in preventive medicine. We can stop the problem before it even happens.

5 Type 1 Diabetes

Type 1 diabetes is an autoimmune disease, meaning our own immune cells attack a part of our body. This is obviously counterintuitive and leads to severe complications. In this case, it is the beta cells of the pancreas that become compromised. Beta cells produce insulin, the hormone that regulates and processes the sugar that we ingest. Without the release of insulin, the individual will have to receive artificial insulin through injections.

Both adult and embryonic stem cells have been considered in regenerating these destroyed cells. Studies have shown mixed results. Some researchers have had success in replicating these missing beta cells, while others have not.^[6] It is difficult to find the beta cells needed as a base colony, but the medical community is still optimistic about the possibilities that this line of research could bring.

4 Cancer

The way that stem cell research has been applied to cancer is very interesting. First, we have to realize where cancer starts, and that is in our own out-of-control, mutated cells. We do have a self-destruct sequence that takes care of cancerous cells in most cases. However, once the cells build up enough mutations, we can no longer deal with them.

In the specific example of breast cancer, research has led to finding clear genetic markers on our own stem cells that indicate that these cells will go on to rapidly and uncontrollably divide, leading to tumors.

This discovery has opened the door to some amazing opportunities. Once a tumor has started, it is very difficult to stop its growth in many cases. So mastectomies become the answer. We could eventually develop a prescreening method to find these cells and destroy them before the cancer begins.^[7]

3 Autism

How can we possibly use stem cells to help a disorder rooted in so many genes that we can barely wrap our heads around its cause? Believe it or not, it is possible. It is not necessarily the cause we should be concerned about in the case of autism but the effect.

In children with autism, we often see parts of their brains suffering from hypoxia (lack of oxygen). If we introduce healthier blood cells in the brain by growing them with stem cells, we can theoretically improve brain function and lessen the symptoms of autism.

Clinical trials are being conducted on animals, and many researchers are optimistic. Whatever the results, we will still learn a lot about the cause and effect of autism.^[8]

2 Parkinson’s Disease

This neurodegenerative disease is horrible in every sense of the word. It begins in the brain with the death of dopamine-producing neurons. Without this necessary neurotransmitter, movement of the body becomes increasingly difficult. This is when we see the classic signs that come with Parkinson’s disease—difficulty speaking, tremors, and more.

Embryonic stem cells were used to regrow entire dopaminergic neurons in patients suffering from Parkinson’s. With this breakthrough research, patients’ symptoms significantly improved and they got their lives back.^[9]

Unfortunately, the resources for this treatment require four human embryos per person. This is simply not realistic if we want to cure a large group of people. Research is ongoing, and we hope to find a way to treat the masses effectively and efficiently.

1 Entire Organs

What if we could grow entire organs out of almost nothing?

It seems like an impossible feat, but this may become a reality. Organ donors are few and far between, but organ failure is not. Hundreds of thousands of people in America die each year from lung, kidney, liver, and heart failure.

Now imagine if we had ample numbers of perfectly healthy organs engineered from stem cells in all major hospitals just waiting to be placed into hosts who desperately needed them? We could prevent countless deaths in all age groups.

How could this realistically happen? Well, the process differs for each organ. What remains consistent, however, is that a basis is needed to begin the regrowth of a healthy organ.^[10]

The ethics surrounding this are smack-dab in the gray area due to the number of stem cells and intact organs needed to make this possible. There is no doubt that stem cell research could save lives, but is it worth the cost?

I’m a fresh university graduate.