10 Bizarre Ways Our Ancestors Tried to Explain Disease

by Brian Sepp

When we think about modern medicine, we often picture sleek labs, high‑tech imaging, and evidence‑based treatments. Yet the path to today’s knowledge was paved with a parade of wildly imaginative explanations. In this roundup we’ll explore 10 bizarre ways our forebears tried to make sense of illness, from spooky superstitions to dubious science. Grab a cup of tea and prepare to be both amused and astonished.

10 Bizarre Ways That Shaped Early Medicine

10 Spread Of Diseases Caused By Night Air

Night air miasma illustration - 10 bizarre ways

During the medieval era a prevailing theory called miasma held sway. Proponents argued that “bad air” – a poisonous vapour rising from rotting organic matter – was the hidden culprit behind scourges such as cholera, chlamydia, and the Black Death. This noxious breeze seemed to intensify around swamps and, oddly enough, after dark. Consequently, people habitually shut their windows and stayed indoors after sunset to escape the alleged threat.

Even towering figures of the American Revolution were not immune to the fear. In 1776, John Adams and Benjamin Franklin found themselves sharing a cramped inn room. Adams, describing his condition in his autobiography, wrote that he “shut the window close” because he dreaded the night air blowing upon him. Franklin, however, persuaded him to reopen it. The fact that a future president could be convinced by the miasma doctrine illustrates how deeply the idea had penetrated educated circles, not just the unlettered masses. Doctors and scholars alike defended the theory for more than a century.

Curiously, while the logic was flawed, keeping windows shut did confer some incidental health benefits. Closed windows reduced exposure to malaria‑carrying mosquitoes and kept out dampness that could chill the body, thereby averting certain fevers. So there was a grain of accidental wisdom amid the misconception.

By the latter half of the 19th century, the germ theory – championed by pioneers like Pasteur and Koch – finally displaced the miasma model, ushering in a new era of microbiological understanding.

9 Epilepsy Caused By Divine Visitation

Ancient Greek epilepsy myth illustration - 10 bizarre ways

In ancient Greece, the condition we now call epilepsy was believed to be a direct message from the gods. The very term stems from the Greek verb epilambanein, meaning “to seize or possess.” Physicians labeled it a “sacred disease,” and it wore many aliases: “seliniasmos,” “Herculian disease” (because it supposedly afflicted the demigod Hercules), and “demonism.”

Greek scholars thought the disorder was a form of miasma – a polluted, harmful air – that settled upon the soul. They interpreted seizures as divine punishment, linking the affliction to Selene, the moon goddess, and insisting that offending her could summon the fits.

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The Greeks even assigned specific deities to particular seizure characteristics. A fit that featured teeth‑grinding was attributed to Cybele, the nature goddess, while a seizure accompanied by a horse‑like scream was blamed on Poseidon, ruler of the sea, earthquakes, and horses. Healing rituals involved purification ceremonies and the chanting of protective hymns.

8 Leprosy Caused By Divine Retribution

Medieval leprosy punishment illustration - 10 bizarre ways

In the Middle Ages, leprosy was widely interpreted as a sign of divine wrath. Those afflicted were thought to be paying for personal sinfulness, a belief reinforced by numerous biblical passages that portrayed the disease as a punishment from God. Leprosy thus became a dual stigma: a physical ailment and a moral indictment.

Society reacted harshly. Lepers were ostracized, forced to wear clanging bells that warned passersby of their approach, and sometimes even attended a funeral mass that officially declared them dead to the community. The combination of spiritual fear and physical revulsion made leprosy one of the most dreaded conditions of the era.

7 Colds Caused By Waste Matter

Hippocratic cold theory illustration - 10 bizarre ways

Hippocrates, often hailed as the father of medicine, made a surprising claim about the common cold. While he famously rejected supernatural explanations for disease, he nonetheless posited that colds resulted from a buildup of waste matter in the brain. According to his view, when this excess overflowed, it manifested as a runny nose and other sniffly symptoms.

The Greek word for the cold, catarrh, literally means “flow,” reflecting the idea of bodily fluids spilling over. This linguistic legacy persists in modern medical terminology, even though Hippocrates’ waste‑matter hypothesis has long been debunked.

6 Mental Illness Caused By Witchcraft

Medieval witchcraft mental illness illustration - 10 bizarre ways

During the medieval period, anyone displaying signs of mental disturbance was often blamed on witchcraft or demonic possession. Exorcism became the go‑to treatment, and during the Renaissance, burning the afflicted was sometimes considered a “cure.”

Women bore the brunt of this suspicion. The prevailing belief was that women, being physically weaker, were more prone to demonic influence. The uterus, in particular, was singled out as a source of evil; it was thought that during menstruation a woman’s blood turned into a venomous substance capable of contaminating others.

Adding another layer of mystique, physicians argued that imagination itself could produce physical changes, equating it with witchcraft. They claimed that the uterus could receive harmful images, while the spleen generated them. Consequently, both organs were deemed potential conduits of pathological visions, giving women a “double source” of supernatural danger compared to men, whose spleen alone was implicated.

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5 Hysteria Caused By A Wandering Womb

Ancient Greek wandering womb illustration - 10 bizarre ways

In ancient Greek medicine, women who exhibited any form of mental distress were diagnosed with hysteria, a condition thought to arise from a “wandering” uterus. The physician Aretaeus described the womb as capable of shifting up, down, left, or right within the body, each direction producing distinct symptoms. An upward migration caused lethargy and vertigo, while a downward drift led to choking sensations, loss of speech, and even sudden death.

Treatments were as inventive as the theory. Physicians applied pleasant aromas, such as honey, to the vagina, hoping the sweet scent would lure the womb back to its proper place. Conversely, foul smells were used to push the organ away from the upper body. Other remedies included chewing garlic cloves, alternating hot and cold baths, frequent sexual activity, and encouraging regular pregnancies to keep the uterus “occupied” and prevent it from roaming.

4 Porphyria Explained As Vampirism

Porphyria vampire myth illustration - 10 bizarre ways

Legends of vampires have haunted humanity for centuries, but modern medicine suggests that a rare genetic disorder called porphyria may have seeded many of these stories. In the Middle Ages, limited scientific knowledge meant that the striking symptoms of porphyria were easily misread as supernatural.

Patients with porphyria are extremely sensitive to sunlight; exposure can cause severe disfigurements to the hands, feet, or face, sometimes resulting in mutilated features, receded noses, ears, or lips, and excessive hair growth that made sufferers resemble wolves or other beasts. The disease can also produce erythrodontia – a reddish hue to the teeth – and gum recession that mimics fangs, reinforcing the vampire image.

Because treatments like heme injections were unavailable, afflicted individuals may have instinctively sought the blood of others to relieve symptoms, inadvertently giving rise to the myth that vampires crave blood. The hereditary nature of porphyria could also explain why “vampire bites” were thought to turn victims into new blood‑suckers.

3 Ulcers Caused By Stress

Ulcer stress myth illustration - 10 bizarre ways

In the mid‑19th century, William Brinton was among the first physicians to describe peptic ulcers, yet without modern diagnostics the cause remained a mystery. Lacking a bacterial culprit, doctors turned to lifestyle and psychological factors, concluding that poor diet, smoking, and especially stress drove excess stomach acid, leading to ulcers.

Prominent clinicians like Arvey Rogers and Donna Hoel even suggested that an ulcer was a badge of hard work, implying that those who didn’t develop one weren’t stressing enough. Treatments centered on antacids and lifestyle changes, while severe cases sometimes required stomach removal or fatal bleeding.

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The tide turned in the early 1980s when Robin Warren identified the bacterium Helicobacter pylori and Barry Marshall, his colleague, boldly ingested the organism to prove causation. Within days Marshall developed gastritis, the precursor to an ulcer, and his self‑experiments finally convinced the medical world that bacteria—not stress—were the true cause, paving the way for antibiotic therapy.

2 Autism Caused By The Lack Of Maternal Warmth

Refrigerator mother autism myth illustration - 10 bizarre ways

When child psychiatrist Leo Kanner first described autism in a 1943 paper, he went beyond cataloguing symptoms and turned his gaze toward parents. Observing a small group of highly intelligent families, Kanner concluded that autistic children were raised in emotionally frigid households, where mothers and fathers offered little warmth.

He famously claimed that these parents were “just happening to defrost enough to produce a child,” and the notion quickly morphed into the infamous “refrigerator mother” theory. Influential figures like Bruno Bettelheim reinforced the idea, suggesting that parental coldness was the root cause of autism.

By the early 1960s, advocates for autistic families began to challenge the theory, and Kanner eventually softened his stance. Nonetheless, the refrigerator mother hypothesis lingered into the 1970s, and remnants of it can still be found in some corners of the world, including parts of Europe and South Korea.

1 Birth Defects Caused By Maternal Impressions

Maternal impressions birth defect illustration - 10 bizarre ways

The theory of maternal impressions held that a pregnant woman’s strong emotions, fears, or desires could imprint themselves onto the developing fetus, shaping its physical appearance. Popular in the 18th century, this idea was employed to explain a variety of birth defects. For instance, a child born deaf might be blamed on the mother having been startled by a loud noise during pregnancy.

The concept traced back even further. Ancient Greek physician Galen asserted that if a mother gazed at a particular statue, her child could inherit its likeness. Consequently, expectant mothers were encouraged to view beautiful artworks, hoping to produce attractive offspring.

Beyond facial features, the theory claimed that a mother’s cravings could dictate birthmark patterns. A woman with a penchant for strawberries might give birth to a child bearing a strawberry‑shaped mark on its skin.

The maternal impressions doctrine persisted through the Middle Ages, the Renaissance, and into the 18th century before being rigorously challenged by anatomist William Hunter. By the late 19th century the idea was finally discarded, leaving behind a fascinating footnote in the history of medical thought.

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